I would never hunt a bear but if i was in bear country with known bear attacks on humans i would not trust bear spray.
so question, would a 6.5 creedmoor round give any protection? The round is pretty fast and would probably give a 2000 pound grizzly something to think about but it might not be enough especially if the bear is angry and focused on attack.
in a perfect world tho i would just buy a 375 h&h.