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Rutgers researchers may have stopped HIV

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Graves
Posts: 460 - Karma: 16
Piscataway, N.J. — Researchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published report.

The drugs, called DAPYs, mimic the virus by changing shape, which enables them to interfere with the way HIV attacks the immune system.

Tests conducted in conjunction with Johnson and Johnson have shown the drug to be easily absorbed with minimal side effects. It also can be taken in one pill, in contrast to the drug cocktails currently taken by many AIDS patients.

“This could be it,� Stephen Smith, the head of the department of infectious diseases at Saint Michael's Medical Center in Newark, said. “We're all looking for the next class of drugs.�

A research team led by Rutgers chemist Eddy Arnold pre-published details of the most promising of the three drugs, known as R278474, last month in the electronic edition of the Journal of Medicinal Chemistry. Full details will be published in the journal in early 2005.

Dr. Arnold, 47, has worked at dismantling the AIDS virus over the last 20 years. He uses X-ray crystallography, a technique to determine the structure of molecules, the smallest particles that can retain all the characteristics of an element or compound.

The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV's key protein.

“Reverse transcriptase is very important in the biology of AIDS,� Dr. Smith said. “If you can really inhibit reverse transcriptase, you can stop AIDS.�

The optimism about R278474 stems from its potential to interfere with an enzyme that the virus needs to copy and insert itself into a human cell.

“We're onto something very, very special,� Dr. Arnold said.

Dr. Arnold established his lab at Rutgers' Center for Advanced Biotechnology and Medicine in 1987. His current 30-member research team is partnered with Johnson and Johnson subsidiaries Janssen Pharmaceutica and Tibotec-Virco NV.

An important advancement in Dr. Arnold's research came in 1990 when Belgian scientist Paul Janssen was added to the collaboration. Dr. Janssen, considered a drug pioneer, published a paper that year that described a new drug that blocked reverse transcriptase but caused resistant strains of the virus to pop up too quickly.

Dr. Janssen sought out Dr. Arnold, who used crystallography to detail the structure of RT. Their work ultimately led to the RT inhibitors.

“We may eventually win the war against HIV/AIDS. That would be an extremely rewarding and satisfying outcome,� Dr. Arnold said.


HUGE. Hopefully it is a success.




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Dec 14 2004 1:56PM
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tandan83
Posts: 2783 - Karma: 141
holy shit. let's hope it works





free ipods for everyone!!!
Dec 14 2004 2:10PM
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Kornn101
Posts: 3534 - Karma: 25
thats nutty, can i find it on msnbc or something?
-Anthony
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Dec 14 2004 2:13PM
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rhcp
Posts: 2598 - Karma: 18
that would be awesome.
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Dec 14 2004 2:22PM
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-=koLLac=-
Posts: 4122 - Karma: 11
maybe I'll survive after all









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~mommy
Dec 14 2004 2:38PM
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fourdskate
Posts: 1119 - Karma: 10
go rutgers
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no true, but you cant judge my english like you judge someone elses that live in for an example the US.. but still you can point out that, but not when i ask something that have something to do about flowers-dallan
Dec 14 2004 2:39PM
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Dr.Dealgood
Posts: 2587 - Karma: 1,352
Hahaha Kollac.

Well this is great news. Keep us posted.
-AndrewP
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Per solitudinem ardere in remedium formidinis dictitabat.
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Dec 14 2004 2:46PM
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asac
Posts: 12485 - Karma: 17
this is momumental.





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Future Canadian
Dec 14 2004 2:46PM
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oO~sKiErGirL~Oo
Posts: 2314 - Karma: 21
yeah that is totally awesome, lets just hope it can be made cheaply enough to ship that stuff over to africa.


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Dec 14 2004 2:50PM
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dbstar
Posts: 2038 - Karma: 20
dont get your hopes up. thats all i have to say

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Eternal Nothingness is Okay if Your Dressed For It



Dec 14 2004 3:02PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
Please note: that this was done only with the help (read financial backing) of a HUGE drug and pharma company, Johnson and Johnson. so to all of you who like to cry about having to pay for prescription drugs in this country, remember that the bulk of what you pay is going to research like this.















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 14 2004 3:03PM
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MattMcGinnis
Posts: 2396 - Karma: 73
we were talking about aids in both social studies and science today. i guess a couple dudes in the industrial revolution would be ppretty pissed right now.





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Logic Headware
Dec 14 2004 3:04PM
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ATLANTASKI
Posts: 6009 - Karma: 11
YAY GO RUTGERS!!!

$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$

KNUCK IF YOU BUCK BWYA



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Dec 14 2004 3:21PM
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plorr
Posts: 3131 - Karma: 528
this is good news. very good news
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Dec 14 2004 3:25PM
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dspin7x
Posts: 6414 - Karma: 63
This is the worst news I have heard all week.
Dec 14 2004 3:33PM
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aggro_sk8
Posts: 2760 - Karma: 18
yay, id be a shame for people to liove, wouldnt it?
-joe

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Dec 14 2004 3:34PM
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tandan83
Posts: 2783 - Karma: 141
too bad it wasnt ten years ago, i would have one more uncle then





free ipods for everyone!!!
Dec 14 2004 3:58PM
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Joe.
Posts: 2888 - Karma: 24
africa is going to bow down to us







LISTEN TO NS RADIO
Dec 14 2004 4:01PM
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jarossamdb7
Posts: 6322 - Karma: -10
'yeah that is totally awesome, lets just hope it can be made cheaply enough to ship that stuff over to africa.'

ya, not gonna happen. that shit will be way more expensive then what is avalible now, no matter how much it actually costs to make. this is priced for desierability here in a America... Bush has underfunded the African Aids Fundation o whatever it is by a shittload. he started it in 2000 and by 2010 he said he would have giuven it like 3 billion. so far, funding is definatly not on track.

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Democrats are sexy: since when have you seen a good looking peice of elephant?

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Dec 14 2004 4:07PM
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Ice-Is-Scary
Posts: 0 - Karma: 87
^ see once again Bush hates blacks and is poisoning them with AIDS. HEY LETS BITCH ABOUT THE BUDGET! HEY LETS BITCH WHEN BUSH CUTS THINGS OUT OF BUDGET!


We pay our debt sometimes.
Dec 14 2004 4:13PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
jaross, first off, do you have any idea how much it costs to make any new drug, let alone one like this? theres a reason that drugs are pricey. on average it costs $800,000,000 to bring any new drug on the market. some are more and some are less. im guessing this AIDs drug was probably more. if you want to have this country adopt a more canadian like perscription drug policy, then you can kiss drugs like this goodbye. because you know what? pharma companies have to turn a profit if theyre going to keep putting out new products. so can it.

















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 14 2004 4:26PM
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Bob_Loblaw
Posts: 8384 - Karma: 38
what the fuck. i just discovered this. i was about to have a press conference and release it tomorrow afternoon. HE STOLE MY WORK!
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Dec 14 2004 4:31PM
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SmoKinSkier
Posts: 5501 - Karma: 20
Dont hold your breath ppl they have had many similar breakthroughs with cancer and other treatments. Insurnace companies and other afiliates will do their best to make sure it takes at least 10 years to go public if at all!




Pete is currently sulking around Mt. Hood, shooting with Poor Boyz Productions and hitting on Kristi Leskinen. She hates guys, Pete lamented, so it’s not going good. Apparently Canada isn’t the only thing that’s tough for Pete to get into.
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Dec 14 2004 4:37PM
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Lateralis
Posts: 1228 - Karma: 332
ill make sure to get aids to see if this vaccine works




My time is winding down.............just wait for it
Dec 14 2004 5:10PM
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jarossamdb7
Posts: 6322 - Karma: -10
ya that is definatly true^

and Anewmorning, i didnt say the Canadian system was perfect, however ultimatly it would save more lives then ours. im sure thye have research buildings and shit too. and if it costs so much to make drugs, how come Canada can offer some much cheaper then the same ones sell for here? someone is making alot of money (drug company ceo maybe?)
((((((((((((((((((((((((((((((((((((((()))))))))))))))))))))))))))))))))))))))

Democrats are sexy: since when have you seen a good looking peice of elephant?

www.johnkerryisadouchebagbutimvotingforhimanyway.com

''When they attacked us'' - Rudolph Giuliani former republican mayor of NYC referring to Iraq in an interview on NBC news after the presidential debate
Dec 14 2004 5:12PM
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jarossamdb7
Posts: 6322 - Karma: -10
refering to what smokinskier said^
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Democrats are sexy: since when have you seen a good looking peice of elephant?

www.johnkerryisadouchebagbutimvotingforhimanyway.com

''When they attacked us'' - Rudolph Giuliani former republican mayor of NYC referring to Iraq in an interview on NBC news after the presidential debate
Dec 14 2004 5:12PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
canada offers them cheaper because theyre getting them from the US. theyre american drugs bought and resold at a base price. socialism is a prescription for mediocrity.















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 14 2004 5:33PM
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lipen69
Posts: 2301 - Karma: 16
groovey, can you say unsafe sex?

(tom)

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my school mates always said that they would fuck anything that could walk. i never saw why i had to limit myself.
Dec 14 2004 5:46PM
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bigJ
Posts: 3148 - Karma: 10
sorry, still no cure for herpes



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Dec 14 2004 5:47PM
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FUUUCK
Posts: 18426 - Karma: 4,888
thats great news
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'You're from Ontario, and you're an idiot, meaning that your opinion can pretty much automatically be dismissed worthless. Yes, I can back that up, I used to live there. Moving to BC really opened up my eyes to what skiing is really about. HINT: Skiing isn't about tiny verticals, shit talking, and private clubs galore. Get the fuck out of Glen Eden and Craigleith or Caledon, and get real.'-what jib this thinks of me
Dec 14 2004 5:57PM
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roadgaptoneckgrind
Posts: 546 - Karma: 23
reverse transcriptase inhibitors have been around for a long time. This is how AIDS works...the virus gets into your cells and then inserts its genome into YOUR DNA. Once its in, there is absolutly no way to get it out, besides killing the infected cell. Once inserted into your DNA it can just chill out for a while and do nothing, or maybe after a while decide to use YOUR DNA REPLICATION MECHANISMS to produce HIV virus protenis that eventually assemble into complete virus particles, which are released from that cell and go on to infect others. Reverse transcriptase inhibitors work because they prevent the HIV RNA from being converted to DNA (only when its converted to DNA can it insert into your DNA). SO really...it only prevents HIV spread, and does nothing to get the HIV DNA out of your cell that is allready there. ANY CELL THATS INFECTED WITH HIV HAS IT FOREVER...when that cell divides, it it will also has the HIV gene and can produce new HIV viruses. RT inhibitors may be able to keep the virus under contoll, but cant get rid of it. you have to kill infected cells to get rid of it. If infected cells include the vast majority of your body...then your in trouble. Sounds like this new drug can stop HIV integreation into uninfected cells, but a cell that is already infected it will continue to produce new virus that will have to be dealt with by the immune system, and depending on the levels of infection, RT may or may not help you get better. They do work though, and increase lifespan dramatically...just wont completly cure you.



( . Y . )
Dec 14 2004 6:04PM
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roadgaptoneckgrind
Posts: 546 - Karma: 23
oh ya...and herpes is troublesome because it hides out in neurons in the brain, where the immune system cells never get to. I guess you could make a drug to kill herpes infected neurons...but depending on how much you use those nerurons in the first place...you may not want to do that.



( . Y . )
Dec 14 2004 6:09PM
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Trash
Posts: 682 - Karma: 10


If the people with AIDs are going to die, then who is?



Dec 14 2004 6:12PM
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ESB
Posts: 9274 - Karma: 10,648
thanks for that info roadgap, that brought some clarity.


'Oh, he's very popular, Ed. The sportos, the motorheads, geeks, sluts, bloods, waistoids, dweebies, dickheads--they all adore him. They think he's a righteous dude.'
Dec 14 2004 6:35PM
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Capt.Flannel
Posts: 10928 - Karma: 36
Where did you find this article? any link?




open up, we're coming inside. What's it feel like to know you're gonna die?
Dec 14 2004 6:55PM
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Bangor
Posts: 9599 - Karma: 129
so, to sum up the information that's been presented so far, it seems as if there is a very early stage possiblity of a HIV vaccine in development?

if you're already got it, your still screwed, but you could be vaccinated against it, like smallpox was back in the day?

in theory, if it's working the way I think it is, AIDS/HIV could eventually be eradicated from the planet?
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Dec 14 2004 7:10PM
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Boards
Posts: 849 - Karma: 27
anewmorning, drug companies will still make sutpid amounts of cash even if they sell a drug for less as more people will have access to it. its just greed that drives companies to keep pricse high.

as fat mike says 'when one makes 20 million, 10000 people lose' and i do wonder what keeps that one from swollowing a shotgun. i suppose no ethics.
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Dec 14 2004 8:04PM
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-=koLLac=-
Posts: 4122 - Karma: 11
anewmorning, you have some dumbass ideas there...sorry man, we have pretty much the same drugs and they don't cost us jack...I can get the same antibiotics that cost 90 dollars in the US in slovakia for about 5 bucks. please explain me how that works because I cannot find the answer here. I'm sure we're not buying the American stuff (and speaking of US drugs...they're made in Ireland)...









i hope harvey bans you just so i can piss on your digital grave.

~mommy
Dec 15 2004 9:56PM
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petek
Posts: 8762 - Karma: 12
this could turn people into zombies...



Cuddle? You fag!
Dec 15 2004 10:18PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
i dont see how the ideas are 'dumbass' for two reasons. fist, they arent my ideas per se. i was talking about an article in newsweek that i read about it, so take up your differences with howard fineman, not me.

second, yes, i know that one of the largest pharma manufacturers, merck has plants in and out of the US. so what? lots of US companies have plants outside the country. their earnings still go into the US GNP.

the reason that you can get american drugs cheaper in countries like Canada, and i am assuming Slovakia, is because there are government controlls on how high the price can be. this is how things are in a socialized nation. youre paying the extra in your sales tax.

in america, there is now price ceiling on products generally, and this is certainly the case for the drug companies. they sell not only to american consumers at market prices, but they can also sell to the national governments of other countries, at whatever price is agreed on. the govenments of those countries then affix whatever price they think is beneficial for their country, and make them available for that price.

so, the problem here is that if american comsumers run across the boarder to buy drugs at socialist prices, the market in the US will fall flat (this is hypothetical) as i mentioned before, if no one is going to buy the drugs at the US market price, then the price has to come down right? right. so what happens then, is that Merck and pfizer, and other manufacturers bring in less profit. as the newsweek article mentioned, it costs roughly $800,000,000 in r&d to bring a new drug on the market, due to FDA standards, and other mandated tests. that is how we keep debachles like the one that merck just went through to to a minimum.

so, if the drug companies arent turning as large of a profit anymore, due to governmental price ceilings, where are they going to come up with the 800 million dollars to bring out new products like the one mentioned in this thread? well, the answer is, either the government, or nowhere. clearly the private sector is going to produce greater results than another government department with all kinds of buerocracies to entangle and slow things down.

really the proof is in the results. you can look at which nations are the most productive, and which have contributed more to the world than others. socialism is a recipit for mediocrity. this is just another example of that.















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 15 2004 10:32PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
that one sentance should read 'no price ceilings' instead of 'now.'















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 15 2004 10:34PM
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petek
Posts: 8762 - Karma: 12
i still say people will turn into zombies from this drug



Cuddle? You fag!
Dec 15 2004 10:38PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
economics aside, youre probably right.















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 15 2004 10:40PM
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petek
Posts: 8762 - Karma: 12
roadgapwhatever ure name is, you basically just described a virus. HIV is special though, it goes right after your immune system, destroying your ability to make white blood cells and platelets. Once this has happenned, a common cold can kill you, or even cutting yourself shaving. Because you have no platelets, you cant heal properly and that allows even more pathogens to get into your body.
However, the cure they are proposing, unless i am incorrect, stops HIV from causing AIDS. You can still be a carrier of HIV, and if HIV has allready mutated into AIDS, that damage is irreversible.
So what we have here, is a genetically modified protein, which acts just like a virus to stop a virus from reproducing. Essentially, we have created a true 'anti-virus', there is no way to be able to predict exactly what happens in the long run, it could mutate itself, and pose an even bigger problem(hell, we could even create an airborn HIV strand, say goodbye to most of humanity or even worse, turns people into zombies). We have no idea what we are dealing with, and without at least another 10 years of research, and then 10 years before it gets onto the market. In 20 years, a substantial part of africa, asia and parts of europe will have a considerably tough time fighting aids. I know it sounds pessimistic and very far fetched, but i really dont see a real cure on the horizon.



Cuddle? You fag!
Dec 15 2004 11:03PM
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Von
Posts: 4869 - Karma: 21
wait your saying this means i can have shamless sex without fear of dying see you guys im outa here

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Dec 15 2004 11:05PM
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Apple
Posts: 7906 - Karma: 33
anewmorning, you have said some of the most ridicilous things. Drug companys put next to no money into solving things like HIV and cancer. almost all of their research goes into cold medication. Second, canadians pay the same for their drugs. I dont get free precription drugs when im sick, i have to pay for everything. Just my taxes go and help pay for it, so i dont pay as much. I dont know alot about the economics of it, but i do know that drug companies spend most of their money on medications which make us feel comfortable and have nothing to do with saving lives.
-Thom Savery

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Dec 15 2004 11:34PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
oh, okay, my bad. im sure this AIDS drug that came from 25 years + of research was really cheap. and theres a reason canadians pay less for drugs... oh wait, i just wrote a bloody page on why. because theyre subsidised. i never said you didnt pay for em!















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 15 2004 11:53PM
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guddgulf17
Posts: 3037 - Karma: 10
awesome. a possible cure for aids would save a lot of people
binding destruction count: 2 so far this season, one pair of lines and one pair of rossis: what will be next?
Dec 15 2004 11:59PM
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jarossamdb7
Posts: 6322 - Karma: -10
anewmorning, what you just said, is that taxes are highr to pay for the difference of drugs being cheap. dont you think that infact it is to pay for all the extra goverment jobs that are apart of their health system along with other scocialist things they may have? also, do canadians pay for perscription grugs or are they free to go along with like when you guys brake your arm it is free to get it fixed?

becuase if they are free or whatever, Anewmorning, you dont have a point. if they arnt, and Canadians do infact have to pay money whenever they get perscription drugs, you may or may not have a point, what your saying is only a possibility.
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Democrats are sexy: since when have you seen a good looking peice of elephant?

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''When they attacked us'' - Rudolph Giuliani former republican mayor of NYC referring to Iraq in an interview on NBC news after the presidential debate
Dec 16 2004 6:47PM
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wilkesyachtingco
Posts: 4425 - Karma: 41
its not a question of what price the canadian citizens buy them at, as their government already has that taken care of. what the problem could be, is when americans go and start buying them in canada. im telling you, this isnt rocket science. these arent MY points here.















Mercy's eyes are blue
When she places them in front of you
Nothing holds a roman candle to
The solemn warmth you feel inside
Dec 16 2004 7:05PM
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ScratchCobra66
Posts: 3688 - Karma: 11
How ligit is this information?





What matters is what your doing. Not what they're doing.
Dec 16 2004 8:04PM
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