I would seriously not be able to choose which one to give up. An argument for each:
1. Smell is the sense that is closest linked to memory. You know how whiffs of your ex's perfume or cologne brings back memories or how powerful the smell of "winter" is? Yeah. I can't part with that.
1.5. Taste = smell. Seriously would not be able to go without peanut butter or french fries or perfectly ripe peaches or macaroni and cheese.
2. No way would I ever be blind. This world is too damn gorgeous.
3. Cannot be deaf. I'm really into music so that would turn me into a Beethoven and I am no way as talented as that guy was.
4. Touch? Nuh uh. I like being able to feel thank you very much. I think this is one of if not my favourite sense.
You can't have a full experience without all your senses. I with there was something in medicine that could CURE blindness, CURE deafness, not just help/remedy it. Because missing a sense or even having one of your senses weaker than the other would be the most painful thing to me, and I feel like those of us who do not have the choice as to whether or not we are born or become blind/deaf/without a nose have been dealt extremely shitty cards in life.