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Many biologically active molecules are chiral, including the naturally occurring amino acids (the building blocks of proteins), and sugars. In biological systems, most of these compounds are of the same chirality: most amino acids are L and sugars are D. Typical naturally occurring proteins, made of L amino acids, are known as left-handed proteins, whereas D amino acids produce right-handed proteins.
The origin of this homochirality in biology is the subject of much debate.[10]
Most scientists believe that Earth life's "choice" of chirality was
purely random, and that if carbon-based life forms exist elsewhere in
the universe, their chemistry could theoretically have opposite
chirality. However, there is some suggestion that early amino acids
could have formed in comet dust. In this case, circularly polarised
radiation (which makes up 17% of stellar radiation) could have caused
the selective destruction of one chirality of amino acids, leading to a
selection bias which ultimately resulted in all life on Earth being
homochiral.[11]
Enzymes,
which are chiral, often distinguish between the two enantiomers of a
chiral substrate. Imagine an enzyme as having a glove-like cavity that
binds a substrate. If this glove is right-handed, then one enantiomer
will fit inside and be bound, whereas the other enantiomer will have a
poor fit and is unlikely to bind.
D-form amino acids tend to taste sweet, whereas L-forms are usually tasteless. Spearmint leaves and caraway seeds, respectively, contain L-carvone and D-carvone - enantiomers of carvone. These smell different to most people because our olfactory receptors also contain chiral molecules that behave differently in the presence of different enantiomers.
Chirality is important in context of ordered phases as well, for
example the addition of a small amount of an optically active molecule
to a nematic phase (a phase that has long range orientational order of
molecules) transforms that phase to a chiral nematic phase (or
cholesteric phase). Chirality in context of such phases in polymeric
fluids has also been studied in this context.
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Copied from Wikipedia, but you get the idea. Using chirality in chemistry you could explain left and right orientation to an alien life form, assuming they understand basic Orgo. Chances are they will so it should work, but there are still flaws of course.