Here are a few ideas:
1. You can discuss the ways in which Frankenstein is alienated throughout the book.
-this can easily apply to anyone's life. Give an example of a time in which you felt outcasted from
your friends or a group of people and how it felt.
-Perhaps this alienation drove Frankenstein to kill.
-If you think that is true than you can give examples of how alienation led to the columbine massacre or V-tech shooting.
2. This is a big one; talk about knowledge and its abuses.
-Example in Frank was obviously his creation.
-Other examples include stem cells, nuclear weapons, cloning.
Hope this helped!